酶响应的两性PEG-dendron杂交体及其组装成智能菌根纳米载体
Assaf J Harnoy1, Ido Rosenbaum, Einat Tirosh
1Department of Organic Chemistry, School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University , Tel-Aviv 69978, Israel.
Journal of the American Chemical Society
|February 27, 2014
概括
使用聚乙烯基甘 (PEG) 和树枝,创建了酶响应的. 这些智能纳米载体在酶激活时分解,为先进的输送系统提供可调节的药物释放率.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 由于酶特异性,酶响应性菌根对向药物递送有前途.
- 开发模块化和高效的合成方法对刺激反应的纳米载体至关重要.
研究的目的:
- 设计和合成用于酶响应性微粒的模块化两类块共聚物.
- 研究这些纳米载体的自组装,拆卸动力学和货物释放机制.
主要方法:
- 合成两类块共聚合物,结合线性聚乙烯基醇 (PEG) 和酶响应性疏水性树枝.
- 使用动力学研究对状纳米容器的形成和酶分解的表征.
- 通过调整 PEG 链长度来调节拆卸速度.
主要成果:
- 成功合成了模块化的PEG-dendron杂交物,这些杂交物在水溶液中自组装成微粒.
- 证明了由酶触发的微粒分解,导致封装货物的释放.
- 建立了PEG长度和片分解率之间的相关性,使控制释放成为可能.
结论:
- 开发了一种多功能平台,用于创建可调节释放配置文件的酶响应.
- 这些聪明的双胞胎混合体有望制造具有可调节药物释放率的纳米载体.
- 模块化设计促进了对酶触发的拆卸机制的详细研究.
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