循环烯循环添加剂与无环法兰: (+) 和 (-) -frondosin B和 (+) -frondosin A的总合成

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E Zachary Oblak1, Michael D VanHeyst, Jin Li

  • 1Department of Pharmaceutical Sciences, University of Connecticut , 69 N. Eagleville Road, Storrs, Connecticut 06269, United States.

Journal of the American Chemical Society
|March 1, 2014
PubMed
概括

研究人员使用一种新的循环添加和操纵策略实现了非对称的frondosins A和B总合成. 弗朗多西因A表现出针对B细胞系的选择性抗增殖活性,与弗朗多西因B不同.

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