细胞谱系分析揭示了一些鸟类神经细胞的多能性
1Department of Developmental and Cell Biology, University of California, Irvine 92717.
Nature
|September 8, 1988
概括
这项研究表明,个体神经细胞具有多能性,能够在离开神经管之前形成多种细胞类型. 这一发现推动了我们对发育生物学和细胞系确定性的理解.
科学领域:
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
背景情况:
- 了解前体细胞如何分化为多种细胞类型是发育生物学中的一个基本问题.
- 神经是一种短暂的胚胎结构,可以产生各种各样的细胞类型,但单个神经细胞的潜力仍然很大程度上是未知的.
研究的目的:
- 为了研究个体神经细胞的发育潜力.
- 要确定单个神经细胞是否预先确定形成特定的细胞类型,或者它们是否具有多能性.
主要方法:
- 光微注射重要的染料 lysinated rhodamine dextran (LRD) 进入个体的背部神经管细胞.
- 追踪和分析标记的克隆,以确定来自单个前体细胞的细胞类型的多样性.
主要成果:
- 来自单个神经细胞的标记克隆通常含有多种分化的细胞类型.
- 这些多样化的细胞类型包括感官神经元,色素细胞,质细胞和神经管细胞,表明显著的多功能性.
结论:
- 至少一些神经细胞在从神经管迁移之前具有多能性.
- 这一发现挑战了早期神经的预定细胞命运的概念,并突出了这些细胞的可塑性.
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