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选择性甲基化组织蛋白H3变异H3.1调节异色染色素复制

Yannick Jacob1, Elisa Bergamin, Mark T A Donoghue

  • 1Howard Hughes Medical Institute-Gordon and Betty Moore Foundation, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Science (New York, N.Y.)
|March 15, 2014
PubMed
概括

基因素修饰酶ATXR5选择性地甲基化基因素H3.1,使其与H3.3.3区分开来. 这种机制在DNA复制过程中保护H3.3基因免受异色染色.

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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