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在酶性C-H键氧化过程中指导群控制的区域选择性

Solymar Negretti1, Alison R H Narayan, Karoline C Chiou

  • 1Department of Medicinal Chemistry, §Life Sciences Institute, ⊥Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|March 18, 2014
PubMed
概括

酶基化区域选择性可以通过基质工程来调节. 将天然基替换为合成基会改变P450单氧酶PikCD50N-RhFRED的作用.

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