抗微生物金属聚合物及其生物结合物与常规抗生素对抗多药耐药细菌
Jiuyang Zhang1, Yung Pin Chen, Kristen P Miller
1Department of Chemistry and Biochemistry, and ‡Department of Environmental Health Sciences, University of South Carolina , Columbia, South Carolina 29208, United States.
Journal of the American Chemical Society
|March 18, 2014
概括
新的充电金属聚合物通过保护传统药物和杀死细菌来打击抗生素耐药性. 这种方法为对抗MRSA等多药耐药菌株提供了希望.
科学领域:
- 聚合物化学 聚合物化学
- 抗菌研究 抗菌研究
- 材料科学 材料科学 材料科学
背景情况:
- 抗生素耐药性是一个日益增长的全球健康威胁,多抗药性细菌,如甲素耐药黄金葡萄球菌 (MRSA) 构成重大挑战.
- 通过诸如β-乳糖酶活性等机制,MRSA使常规β-乳糖抗生素失活,导致治疗失败,死亡率增加和医疗费用增加.
研究的目的:
- 开发一种针对多药耐药细菌,特别是MRSA的新型治疗策略.
- 研究带电金属聚合物与常规β-乳酸抗生素结合的协同效应.
主要方法:
- 合成了一类带电金属聚合物,其中包含了阴阳性甲部分.
- 评估了金属聚合物抑制β-乳糖酶活性的能力,保护β-乳糖抗生素免受水解.
- 评估了金属聚合物的直接杀菌作用,包括细菌细胞溶解.
主要成果:
- 充电的金属聚合物显示出β-乳酸酶的强烈抑制,保持了抗生素如青素-G,氨基素,安培素和塞法林的疗效.
- 抗生素碳酸盐离子和聚合物阴离子部分之间的离子对的形成保护了抗生素免受酶降解.
- 金属聚合物表现出直接的细菌细胞溶解,有助于它们对MRSA的整体有效性.
结论:
- 充电金属聚合物为对抗抗生素耐药细菌提供了一个有希望的协同方法.
- 这一策略可以恢复传统抗生素对抗MRSA等超级细菌的活力.
- 这些发现为设计下一代抗微生物疗法的宏分子支架开辟了新的途径.
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