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Updated: Jun 28, 2026

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内皮细胞特异性肝激酶B1的缺失在体内小鼠中引起内皮功能障碍和高血压

Wencheng Zhang1, Qilong Wang, Yue Wu

  • 1Section of Molecular Medicine, Department of Medicine (W.Z., Q.W., Y.W., C.M., Z.L., X.D., Q.W., M.-H.Z.) and Department of Biochemistry and Molecular Biology (Z.L., M.-H.Z.), University of Oklahoma Health Sciences Center, Oklahoma City; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, China (Y.W., W.L., Z.-Y.Y., M.-H.Z.); and Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China (M.-H.Z.).

Circulation
|March 19, 2014
PubMed
概括

内皮肝肝激酶B1 (LKB1) 损失导致高血压和受损的血管功能通过增加caveolin-1. 恢复AMP激酶活性使这些效应正常化.

关键词:
由AMP激活的蛋白质激酶被AMP激活卡维奥林1 卡维奥林1这种高血压是高血压.氧化合成酶III类型的三氧化.

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