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Updated: May 2, 2026

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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抗生素,泛素通道和亡之间的意外联系

Ivan K H Poon1, Yu-Hsin Chiu2, Allison J Armstrong3

  • 11] The Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA [2] Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA [3] Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA [4] La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.

Nature
|March 21, 2014
PubMed
概括

抗生素trovafloxacin抑制了泛素1 (PANX1) 通道,这些通道对于细胞在亡过程中分解至关重要. 这一发现将抗生素与细胞完整性联系起来,并可能指导开发新的抗菌药物.

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