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Updated: May 1, 2026

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癌细胞对葡萄糖限制和大化物敏感性的代谢决定因素

Kıvanç Birsoy1, Richard Possemato1, Franziska K Lorbeer2

  • 11] Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA [4] The David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [5].

Nature
|March 28, 2014
PubMed
概括

癌细胞通过调节线粒体氧化酸化 (OXPHOS) 来适应低葡萄糖. 在这个过程中的缺陷,由于突变或葡萄糖使用受损,预测对OXPHOS抑制药物的敏感性.

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