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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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在黑色素瘤中对BRAF (V600E) 抑制的可逆和适应性耐药性

Chong Sun1, Liqin Wang1, Sidong Huang2

  • 11] Division of Molecular Carcinogenesis, Cancer Systems Biology Centre and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands [2].

Nature
|March 28, 2014
PubMed
概括

黑色素瘤对BRAF/MEK抑制剂的耐药性可能来自SOX10损失,增加EGFR. 这解释了耐药性,并表明EGFR阳性患者可能从药物假期和再治疗中受益.

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