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孕产妇的视网类药物控制3型先天性淋巴细胞,并设置后代的免疫力

Serge A van de Pavert¹, Manuela Ferreira², Rita G Domingues³

¹1] Department of Molecular Cell Biology and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands [2] Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. [3].

|March 28, 2014

概括

母亲的饮食会影响胎儿的免疫发育. 在子宫内进行的网红酸信号控制着免疫细胞的成熟,影响成人免疫健康和淋巴细胞器官大小.

科学领域:

免疫学免疫学免疫学
发展生物学发展生物学
营养科学营养科学

背景情况:

胎儿营养对成人健康的影响已知,但其对免疫系统发育的影响尚不清楚.
二级淋巴体器官在胚胎发生过程中形成,对免疫反应至关重要.
3型先天性淋巴细胞 (ILC3),特别是淋巴组织诱导细胞 (LTi),对于淋巴细胞有机发生是必不可少的.

研究的目的:

研究母亲饮食和视网膜酸 (RA) 信号在胎儿免疫系统发育中的作用.
阐明母亲营养影响后代免疫力的分子机制.
确定子宫内免疫编程如何影响成人免疫健康.

主要方法:

研究了小鼠模型来分析胎儿ILC3发育和胚胎淋巴体器官的分化.
研究了母亲的视网类药物摄入量和胎儿的RA信号对LTi细胞成熟的影响.
利用基因表达分析识别调节途径,包括转录因子RORγt和RA受体.

主要成果:

胎儿ILC3s在胚胎发生过程中受到细胞自主视网酸 (RA) 信号的调节.
母亲的视网体摄入量和胎儿的RA信号控制LTi细胞分化和成熟.
在RORγt上游,RA信号作用,RA受体直接调节Rorgt位点.
母亲饮食中的视网类药物会影响二次淋巴体器官的大小和成年后代的免疫反应效率.

结论:

孕产妇的营养,特别是视网类药物的摄入量,对于编程胎儿免疫发育至关重要.
在子宫内进行的视网酸信号通过控制淋巴细胞器官的形成,在成年后代中建立免疫健康.
这项研究揭示了母体营养素与免疫结构的发展之间的分子联系,这对抗感染至关重要.

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