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细胞循环调节的Akt酶的激活,通过其基终端的酸化

Pengda Liu1, Michael Begley2, Wojciech Michowski3

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|March 28, 2014
PubMed
概括

Akt (蛋白激酶B) 激活进一步通过细胞循环依赖的酸化在S477/T479.9进行调节. 这一发现将细胞周期进展与癌症中的Akt过活化联系在一起,影响细胞增殖和存活.

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