S L Diamond1, S G Eskin, L V McIntire

  • 1Rice University, Biomedical Engineering Laboratory, Houston, TX 77251.

Science (New York, N.Y.)
|March 17, 1989
PubMed
概括

动脉壁剪切应力显著增加了内皮细胞的组织等离子素激活剂 (tPA) 分泌. 静脉剪切应力和所有水平的等离子原激活剂抑制剂,类型1 (PAI-1) 分泌没有受到影响.

相关概念视频

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...