非编码RNA革命 - - 废除旧规则,创造新的规则
Thomas R Cech1, Joan A Steitz2
1Howard Hughes Medical Institute; Department of Chemistry & Biochemistry, BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80309, USA.
Cell
|April 1, 2014
概括
非编码RNAs (ncRNAs) 执行不同的生物作用,调节基因表达和保护基因组. 这一领域的研究不断挑战对ncRNA功能和机制的现有理解.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 生物化学 生物化学
背景情况:
- 非编码RNAs (ncRNAs) 是具有多种生物功能的关键分子.
- 它们在基因表达调节,基因组保护和DNA合成中发挥作用.
研究的目的:
- 审查ncRNAs在生物过程中的多方面的作用.
- 突出ncRNA研究的动态和不断变化的性质.
主要方法:
- 对已建立和新兴的ncRNA功能进行文献综述.
- 对ncRNA机制的分析,包括结构-功能关系和RNA-蛋白相互作用.
主要成果:
- ncRNAs在转录,后转录和转化层面调节基因表达.
- 许多ncRNAs在RNA-蛋白质复合体中起作用,而另一些则利用RNA结构进行活动.
- ncRNA研究始终揭示新的功能,挑战以前的假设.
结论:
- 在ncRNA研究领域的特点是不断的发现和颠覆既定范式.
- 了解ncRNA复杂性对于推进分子生物学和遗传学至关重要.
相关概念视频
01:20Types of RNA
13.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
13.9K
01:23Types of RNA
61.3K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
61.3K
01:23Types of RNA
19.7K
19.7K
01:20Types of RNA
2.0K
2.0K
02:39lncRNA - Long Non-coding RNAs
7.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
7.5K
02:39lncRNA - Long Non-coding RNAs
2.6K
2.6K