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相关概念视频

Stem Cell Culture01:17

Stem Cell Culture

4.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
Forced Transdifferentiation01:28

Forced Transdifferentiation

1.5K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
1.5K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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3.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.9K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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相关实验视频

Updated: May 1, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

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重新思考分化:干细胞,再生和可塑性

Alejandro Sánchez Alvarado1, Shinya Yamanaka2

  • 1Stowers Institute for Medical Research and Howard Hughes Medical Institute, Kansas City, MO 64110, USA.

Cell
|April 1, 2014
PubMed
概括

细胞分化对于多细胞生命至关重要,正在重新研究. 新发现挑战了长期以来关于干细胞和分化的细胞的概念,促使人们重新评估研究方法.

科学领域:

  • 发育生物学 发展生物学
  • 细胞生物学 细胞生物学
  • 干细胞研究 干细胞研究

背景情况:

  • 细胞分化对于多细胞生物的发展,生长,繁殖和寿命至关重要.
  • 40多年来,细胞分化的调控一直是关键的研究领域.
  • 最近对干细胞 (自然和诱导) 的研究促使人们重新评估已有的定义.

研究的目的:

  • 探索最近的发现如何挑战细胞分化传统概念.
  • 强调需要重新评估细胞生物学中的实验系统和范式.

主要方法:

  • 关于植物和动物细胞分化的最新发现的综述.
  • 对干细胞研究中新型实验操纵的分析.
  • 对已建立的生物范式进行概念性重新评估.

主要成果:

  • 干细胞和分化细胞的既定概念正在被新的发现所侵蚀.
  • 新的实验方法正在揭示细胞命运决定的复杂性.
  • 现有的研究范式可能需要进行重大修订.

结论:

  • 细胞分化的研究正在进入一个新的理解阶段.

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Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells
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Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells

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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

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Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells
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  • 对于未来的进步,需要对实验系统进行批判性重新评估.
  • 跨学科的方法对于推动细胞分化研究至关重要.