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Updated: May 1, 2026

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作为一种抗癌策略, (S) - 克里佐替尼对MTH1进行立体特异向

Kilian V M Huber1, Eidarus Salah2, Branka Radic1

  • 1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

Nature
|April 4, 2014
PubMed
概括

研究人员确定MTH1 (NUDT1) 是RAS驱动癌症中SCH51344的目标. 克里佐替尼 (crizotinib) 的 (S-enantiomer) 选择性地抑制MTH1,破坏核酸平衡并抑制瘤生长,提供了一种新的抗癌策略.

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