鼠标大脑中的一个半尺度连接体
Seung Wook Oh1, Julie A Harris1, Lydia Ng1
11] Allen Institute for Brain Science, Seattle, Washington 98103, USA [2].
Nature
|April 4, 2014
概括
研究人员创建了老鼠大脑的详细地图.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 了解大脑连接对于神经科学至关重要.
- 对于哺乳动物来说,还没有完整的全脑连接数据集.
- C. elegans连接体是目前唯一存在的微观样本.
研究的目的:
- 为小鼠大脑创建一个全面的,细胞层面的,大尺度连接体.
- 为神经电路研究提供基础资源.
主要方法:
- 利用表达增强的绿色光蛋白 (EGFP) 的腺相关病毒载体进行轴突追踪.
- 采用高通量串联双光子断层扫描仪进行成像.
- 开发了一个系统的方法,用于将空间注册到3D参考空间.
主要成果:
- 为小鼠生成了一个全脑连接矩阵.
- 一个计算模型提供了关于连接强度,对称性和网络属性的见解.
- 虚拟轨道图像可视化了3D地形和皮质 - thalamic通路组织.
结论:
- 艾伦鼠标大脑连接图谱是一个新的,免费可用的资源.
- 这本地图书使神经回路的结构和功能研究成为可能.
- 它支持对行为,认知,健康和疾病背后的神经回路的研究.
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