怀孕前低剂量阿司匹林和怀孕结果:EAGeR随机试验的结果
Enrique F Schisterman1, Robert M Silver2, Laurie L Lesher2
1Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Lancet (London, England)
|April 8, 2014
概括
怀孕前低剂量阿司匹林并没有显著改善1到2次怀孕损失的妇女的活产率. 然而,对于那些单一的早期损失的人来说,它显示出希望,尽管不推用于一般预防.
科学领域:
- 生殖医学 生殖医学
- 临床试验 临床试验
- 产科 产科 产科 产科 产科
背景情况:
- 评估孕前低剂量阿司匹林对怀孕结果的影响.
- 研究其在有1到2次妊娠流产史的女性中的有效性.
研究的目的:
- 为了确定是否在怀孕前开始的低剂量阿司匹林可以改善重复流产的妇女的活产率.
- 为了评估预孕的安全性和有效性,低剂量阿司匹林.
主要方法:
- 这是一项多中心,随机,双盲,安慰剂对照试验,涉及1228名女性.
- 妇女每天接受低剂量阿司匹林 (81毫克) 或安慰剂加叶酸.
- 主要结局是活产率,根据治疗意图进行分析.
主要成果:
- 总体而言,低剂量阿司匹林的活产率为58%,与安慰剂相比为53% (p=0.0984).
- 在怀孕20周以下一次性流产的妇女中,使用阿司匹林的活产率显著更高 (62%对53%,p=0.0446).
- 使用阿司匹林时注意到阴道出血增加,但与流产无关.
结论:
- 怀孕前低剂量阿司匹林与改善活产或减少先前一到两次流产的妇女的妊娠损失没有显著相关.
- 在单次早期怀孕流产的妇女中观察到潜在的益处.
- 目前不建议低剂量阿司匹林用于预防这群人群的流产.
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Teratogenicity
4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Study Designs in Epidemiology
1.6K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.6K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.6K

