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铜对于瘤性BRAF信号传递和瘤发生是必需的

Donita C Brady1, Matthew S Crowe1, Michelle L Turski1

  • 1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Nature
|April 11, 2014
PubMed
概括

铜化疗法可以治疗BRAF (V600E) 癌症. 减少铜载体1 (CTR1) 或破坏铜与MEK1的结合,可以抑制BRAF (V600E) 信号和瘤生长.

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