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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
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尼古丁胺N-甲基转移酶倒置能防止饮食引起的肥胖

Daniel Kraus1, Qin Yang1, Dong Kong2

  • 11] Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA [2] [3] Division of Nephrology, Department of Internal Medicine I, Würzburg University Hospital, Oberdürrbacher Straße 6, 97080 Würzburg, Germany (D.K.); Department of Medicine, Physiology and Biophysics, Center for Diabetes Research and Treatment, and Center for Epigenetics and Metabolism, University of California, Irvine, California 92697, USA (Q.Y.); Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, 00290, Helsinki, Finland (E.P.); Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie Medicine New Brunswick, Dalhousie University, Saint John, New Brunswick E2L4L5, USA (T.C.P.); Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China (F.G.); School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland (L.A.).

Nature
|April 11, 2014
PubMed
概括

尼古丁胺胺N-甲基转移酶 (NNMT) 在肥胖和2型糖尿病中被上调. 抑制NNMT可以增加能量消耗,并通过影响NAD+和聚胺代谢来防止肥胖.

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