一个由子向机制定义的临界时期,在小鼠嗅觉球泡中
1Department of Neuroscience, Brown University, Providence, RI 02912, USA.
概括
新的发现表明,嗅觉系统的嗅觉系统.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统的开发和开发
- 感官地图的形成感觉地图的形成
背景情况:
- 嗅觉系统由于持续的神经生成而表现出终身的可塑性.
- 嗅觉感官神经元向嗅觉球中的特定目标 (称为淋巴细胞) 发射.
研究的目的:
- 研究气味受体表达时间在嗅觉地图形成中的作用.
- 为了确定异位异味受体表达是否影响感官轴突向.
主要方法:
- 利用转基因小鼠来表达嗅觉受体.
- 检查了轴突指导和球体形成.
- 进行了嗅觉图的化学剥离.
主要成果:
- 周产期的转基因气味受体表达将轴突重定向到新的球粒.
- 建立后的表达不会导致重新路由.
- 在重新路由后的地图删除阻止了恢复正常地图.
结论:
- 嗅觉感官神经元对淋巴细胞的向是在关键的发育时期确定的.
- 气味受体表达以时间依赖的方式影响感官地图组织.
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