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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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卡斯帕酶-11的激活需要通过IFN诱导的GTPases溶解含有病原体的真空体

Etienne Meunier1, Mathias S Dick2, Roland F Dreier2

  • 1Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

Nature
|April 18, 2014
PubMed
概括

关酸结合蛋白对于非正规的炎症体通路至关重要,该通路检测出格拉姆阴性细菌. 这些蛋白质触发真空溶解,使细菌脂聚糖的检测和随后的caspase-11激活成为可能.

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