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Updated: May 1, 2026

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Listeria monocytogenes Infection of the Brain
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李斯特菌单细胞原体利用细胞分裂促进细胞间的传播
Mark A Czuczman1, Ramzi Fattouh2, Jorik M van Rijn3
11] Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G0A4, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S1A8, Canada.
Nature
|April 18, 2014
概括
李斯特菌利用细胞清除过程 (epherocytosis) 在宿主细胞之间传播. 这种病原体使用形成孔的毒素来产生含有酸胺 (PS) 的囊泡,然后被其他细胞吞,帮助感染.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 细胞生物学 细胞生物学
背景情况:
- 细胞增生对于去除死细胞和保持组织健康至关重要.
- 在垂死的细胞上结合脂氨酸 (PS) 的受体调解了细胞分裂.
- 细菌病原体可以潜在地劫持宿主细胞过程,以造福自身.
研究的目的:
- 为了研究Listeria monocytogenes如何利用efferocytosis进行细胞间传播.
- 为了确定参与这个过程的细菌因素和宿主受体.
主要方法:
- 研究了宿主细胞中的Listeria monocytogenes感染.
- 分析了listeriolysin O (LLO) 和ActA在细菌逃逸和突起形成中的作用.
- 使用体外试验和Timd4淘汰赛小鼠研究了PS结合受体TIM-4的参与.
主要成果:
- 李斯特菌使用LLO破坏宿主细胞膜,形成含有细菌的突起.
- 这些突起被释放为暴露PS的囊泡,促进其他细胞的细胞分裂.
- TIM-4调解了巨细胞对这些囊泡的吸收,促进了细菌的传播.
- 在Timd4的小鼠中,L. monocytogenes的生长有所减少.
结论:
- 李斯特菌单细胞菌活跃利用细胞分裂在宿主体内传播.
- 病原体的细胞间传播机制涉及LLO诱导的膜损伤和显示PS的囊泡.
- 向PS介导的细胞分裂可能是对抗L. monocytogenes感染的治疗策略.
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