肠道TH17细胞对共生细菌抗原的集中特异性
Yi Yang1, Miriam B Torchinsky1, Michael Gobert1
1The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.
Nature
|April 18, 2014
概括
分段丝状细菌 (SFB) 特别诱导肠道中的T-辅助者-17 (TH17) 细胞. 这些TH17细胞识别SFB抗原,影响自身免疫性疾病和粘膜免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- T-助手-17 (TH17) 细胞对于粘膜防御和自身免疫性疾病至关重要.
- TH17细胞在小肠膜内丰富,需要肠道微生物群才能存在.
- 分段丝状细菌 (SFB) 是已知的诱导者TH17细胞和相关的自身免疫条件在动物模型.
研究的目的:
- 为了研究肠道TH17细胞的特异性.
- 阐明不同细菌诱导TH17细胞的机制.
- 了解TH17细胞如何促进组织特异性炎症.
主要方法:
- 从SFB殖民小鼠的肠道TH17细胞中分析T细胞抗原受体 (TCR) 谱.
- 评估TH17细胞分化对SFB编码抗原的反应.
- 与SFB和Listeria monocytogenes进行共同殖民实验,以评估抗原特异性.
主要成果:
- 在SFB殖民小鼠中,肠道TH17细胞表现出独特的TCR谱,与其他CD4 ((+) T细胞的重叠最小.
- 大多数TH17细胞,与其他T细胞不同,识别由SFB编码的抗原.
- 具有针对SFB抗原特异性的TCR的T细胞分化为表达RORγt的TH17细胞,而不考虑其他微生物刺激.
结论:
- 抗原特异性是由产生抗原的细菌决定的,决定了T细胞效应器的功能.
- 这种特异性是了解肠道微生物群如何促进器官特异性自身免疫的关键.
- 研究结果为开发针对特定细菌抗原的新型粘膜疫苗提供了洞察力.
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