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可扩展的控制安装和攻击由Esr1+神经元在中腹下丘脑中部中枢下丘脑

Hyosang Lee¹, Dong-Wook Kim², Ryan Remedios³

¹1] Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, California 91125, USA [2] Howard Hughes Medical Institute, Pasadena, California 91125, USA.

|April 18, 2014

概括

研究人员确定了控制社会行为的腹侧腹中下丘脑 (VMHvl) 中雌激素受体1 (Esr1) 神经元. 它们的激活水平决定了成长和侵略之间的过渡,这对于社交互动阶段至关重要.

科学领域:

神经科学是一个神经科学.
行为生物学行为生物学
内分泌学在内分泌学.

背景情况:

社会行为涉及通过食欲和消费阶段不断升级的兴奋.
腹侧腹中垂体下丘脑 (VMHvl) 参与社会接触.
之前的研究表明,VMHvl的激活会引起攻击,而不是安装.

研究的目的:

为了确定控制社会行为的VMHvl内的特定神经元群体.
研究雌激素受体1 (Esr1) 表达神经元在男性社会相互作用中的作用.
了解神经元活动如何扩展以调节不同的社会行为.

主要方法:

特定的VMHvl神经元子集 (Esr1+和Esr1-) 的光遗传激活和抑制.
对男性社会遭遇的行为分析 (侵略,升级,调查).
在体外成像和体内c-Fos分析以将神经元活动与刺激强度相关联.

主要成果:

对于发起和维持攻击行为,Esr1+VMHvl神经元是充足的,也是必要的.
低强度的Esr1+神经元的光遗传激活促进了安装和调查,而高强度则促进了攻击.
对于社会相互作用的食欲和消费阶段,Esr1+神经元是必需的.

结论:

在VMHvl中的Esr1+神经元协调社会行为的升级.
在Esr1+VMHvl细胞中的神经活动与刺激强度相变,控制社会行为之间的过渡.
这些发现揭示了调节社会互动进展的神经机制.

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