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与癌症相关的PTEN突变体以主导负态的方式抑制PTEN蛋白功能

Antonella Papa1, Lixin Wan2, Massimo Bonora3

  • 1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Cell
|April 29, 2014
PubMed
概括

PTEN蛋白形成二元来调节其活性. 与癌症相关的PTEN突变可能会损害这种功能,导致瘤易感性增加和类似于完全失去PTEN的效果.

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