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Updated: Feb 7, 2026

GPI Anchoring of Proteins in the ER Membrane
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GPI Anchoring of Proteins in the ER Membrane

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在Tus/Ter停滞的哺乳动物复制叉中,BRCA1控制同源重组

Nicholas A Willis1, Gurushankar Chandramouly2, Bin Huang2

  • 1Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

Nature
|April 30, 2014
PubMed
概括

复制分叉停滞可能导致基因组不稳定. BRCA1和BRCA2在停滞的分叉处调节同源重组 (HR),它们的失活导致异常HR,增加癌症风险.

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