在自身免疫性脑膜炎的抗原识别和介导免疫治疗的潜力
D C Wraith1, D E Smilek, D J Mitchell
1Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
Cell
|October 20, 1989
概括
研究人员在一个髓基蛋白自抗原中确定了关键的氨基酸. 一种新型的类比被设计用于阻止T细胞反应,抑制小鼠的自身免疫性疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 这是一种自身免疫力.
背景情况:
- 对自身抗原的T细胞识别在诸如实验性自身免疫脑膜炎 (EAE) 等自身免疫性疾病中至关重要.
- 髓基蛋白 (MBP) 含有脑原性T细胞表位,可触发自身免疫反应.
- 了解T细胞受体 (TCR),主要基因相容性复合体 (MHC) 和自身抗原之间的分子相互作用对于治疗开发至关重要.
研究的目的:
- 描述T细胞识别来自髓基蛋白的脑性T细胞自身抗原的特征.
- 定义涉及自抗原,MHC和TCR之间的相互作用的特定氨基酸.
- 设计可以调节T细胞反应的新,并可能抑制自身免疫性疾病.
主要方法:
- 对主要组织相容性复合体 (MHC) 分子进行结合测试.
- 在实验室中使用来自 (PL/J x SJL) F1小鼠的淋巴结T细胞进行T细胞激活研究.
- 在体内研究以评估自身免疫性疾病的小鼠模型中的免疫性和治疗疗效.
主要成果:
- 确定了对MHC结合和TCR相互作用至关重要的特定氨基酸.
- 一个设计的类型在体外证明了MHC结合和T细胞激活的"异构".
- 这种类似物在体内是非免疫的,并且有效抑制了由原生自身抗原诱导的自身免疫性疾病.
结论:
- 参与T细胞识别的氨基酸残留物的精确定义使得免疫调节的合理设计成为可能.
- 一种异构素c类似物可以通过阻断致病性T细胞反应,作为一种安全有效的治疗剂.
- 这一策略有望通过向特定的自身抗原来治疗T细胞介导的自身免疫性疾病.
更多相关视频
10:47Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies
Published on: October 27, 2016
10.7K
05:55Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
1.4K
相关概念视频
01:20Myasthenia Gravis: Overview and Treatment
3.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.7K
01:26Antigens Involved in Adaptive Immunity
1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
01:19Encephalitis l: Introduction
15
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
15
01:26Encephalitis ll: Pathophysiology
22
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
22