脊柱感觉反的前突触抑制确保了平稳的运动
Andrew J P Fink1, Katherine R Croce1, Z Josh Huang2
1Howard Hughes Medical Institute, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Nature
|May 3, 2014
概括
研究人员确定了特定的脊柱GABAergic内部神经元,控制精确运动的感觉反. 切除这些神经元导致了运动振荡,揭示了顺运动行为的关键增益控制系统.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 脊髓生理学 脊髓生理学
背景情况:
- 熟练的运动精度依赖于感官反和局部抑制电路.
- 脊柱GABAergic内部神经元在感官 afferent 终端上形成独特的轴-轴联接触,调解前突触抑制.
- 这些内部神经元在运动行为中的具体作用仍然不清楚,因为选择性访问存在挑战.
研究的目的:
- 通过基因识别和操纵脊柱GABAergic内部神经元,这些神经元参与了前突触抑制.
- 阐明预突触抑制对目标导向运动行为的贡献.
- 定义运动中的感觉反增益控制的神经基质.
主要方法:
- 利用Gad2作为一个基因入口点来准特定的脊髓内部神经元.
- 在小鼠中激活和切除Gad2表达内神经元.
- 记录了前突触抑制的生理特征.
- 在目标定向的任务中分析了运动行为.
- 采用计算建模来理解感官反收益.
主要成果:
- 目标内神经元的激活表明了前突触抑制的生理特征.
- 对Gad2表达性内神经元的基因切除导致了在达到运动方面显著的缺陷.
- 在内部神经元切除后观察到明显的前肢运动振荡.
- 建模证实,高感官反增益解释了观察到的运动振荡.
结论:
- 确定了Gad2表达的脊髓内部神经元作为前突触抑制的神经基质.
- 证明这些内部神经元构成一个基因连接的增益控制系统,对于顺的运动执行至关重要.
- 预突触抑制在完善感官反以实现精确的运动控制方面发挥着至关重要的作用.
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