耐空气和耐水的稀土瓜尼尼BINOLATE复合物作为多功能不对称催化剂中的实用前催化剂
Jerome R Robinson1, Xinyuan Fan, Jagjit Yadav
1P. Roy and Diana T. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.
Journal of the American Chemical Society
|May 7, 2014
概括
新型与结合的稀土金属BINOLate复合物为Shibasaki提供稳定,易于合成的前催化剂.
科学领域:
- 有机金属化学 有机金属化学
- 不对称的催化剂.
- 超分子化学 超分子化学
背景情况:
- 西巴萨基的稀土金属BINOLate (REMB) 催化剂具有高的反选择性,但很难合成和处理.
- 挑战包括对水分的敏感性和复杂的合成过程,限制了它们的广泛应用.
研究的目的:
- 开发稳定,易于合成的预催化剂,用于西巴萨基的REMB催化剂.
- 为了提高这些有价值的不对称催化剂的处理和稳定性.
主要方法:
- 新型与结合的稀土金属BINOLate复合物的自组装.
- 将酸纳入二次协调领域.
- 开发可扩展的,使用水合稀土前体的露天合成路线.
主要成果:
- 新型与结合的稀土金属BINOLate复合物被成功合成为基板稳定的预催化剂.
- 这些预催化剂在溶液和固体状态下表现出对水分的稳定性.
- 可扩展,高产率,露天合成由廉价的水合稀土起始材料建立.
- 在迈克尔添加,aza-Michael添加和直接Aldol反应中实现了可比或改进的立体选择性.
结论:
- 开发的与结合的稀土金属BINOLate复合物作为Shibasaki的REMB框架的有效和稳定的前催化剂.
- 这些预催化剂克服了先前的合成和处理限制,使得高度选性异对称催化剂的更广泛应用成为可能.
- 简单的合成和增强的稳定性促进了对有机合成的先进催化系统的使用.
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