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通过年轻的系统因素对老化中的老鼠大脑进行血管和神经再生

Lida Katsimpardi1, Nadia K Litterman, Pamela A Schein

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

Science (New York, N.Y.)
|May 7, 2014
PubMed
概括

年轻血液因子和GDF11可以逆转与年龄相关的大脑衰退. 这些在小鼠中的发现显示了治疗神经退行性疾病的潜力,通过使神经性位再生和改善认知功能.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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