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Updated: Apr 30, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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循环[6]pyridine[6]pyrrole:一个动态的,扭曲的宏循环,没有中桥

Zhan Zhang1, Won-Young Cha, Neil J Williams

  • 1Department of Chemistry, The University of Texas at Austin , 105 East 24th Street, Stop A5300, Austin, Texas 78712-1224 United States.

Journal of the American Chemical Society
|May 13, 2014
PubMed
概括

研究人员合成了一种新的氨酸类似物,cyclo[6]pyridine[6]pyrrole,它表现出动态的八号形状. 与二化的质子化和复杂化允许对其结构形式进行控制,从而影响其特性.

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Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
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