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Updated: Apr 30, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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RIPK1 阻断了由 caspase-8 和 RIPK3 介导的早期产后死亡率

Christopher P Dillon1, Ricardo Weinlich1, Diego A Rodriguez1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell
|May 13, 2014
PubMed
概括

受体相互作用蛋白激酶1 (RIPK1) 缺乏导致致死性,但将RIPK1和RIPK3淘汰与caspase-8或FADD删除相结合,可以生存. RIPK1调节细胞死亡途径,影响炎症和亡.

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