特定于模式的甲状腺皮层输入指示后突触L4神经元的身份
Gabrielle Pouchelon1, Frédéric Gambino2, Camilla Bellone1
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Nature
|May 16, 2014
概括
甲状腺皮层 (TC) 输入形状发展皮层神经元. 将触觉输入替换为感知输入导致神经元采用新的感觉功能,改变了电路的发展.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 分子神经科学 分子神经科学
背景情况:
- 脑皮层 (TC) 输入对于皮层区域在发育过程中的模式至关重要.
- 在体感皮层的4层 (L4) 神经元从垂体的腹腔大 (VB) 和后核 (Po) 接收不同的输入.
- 在出生后,L4神经元的身份是塑性的,这表明TC输入影响了分化.
研究的目的:
- 调查TC输入的来源是否指导L4神经元的分子和功能身份.
- 为了确定L4神经元是否可以根据电路组装过程中改变的TC输入来尊重它们的身份.
主要方法:
- 在新生小鼠中的VB核的遗传切除.
- 对主要体感皮质L4神经元上的Po投影的分析 (S1).
- 评估L4神经元在剥离后的分子和功能变化.
主要成果:
- VB 切除导致 Po 投影重新连接到 S1 L4 神经元.
- 重新指定的L4神经元获得了Po-目标神经元特征和压抑的VB-目标特征.
- 这些神经元对触觉刺激和有害刺激都有反应,与正常模式分离不同.
结论:
- TC输入类型特别控制L4神经元的分子和功能差异化.
- 这种输入驱动的可塑性指导了特定模式的神经元和电路特性的发展.
- 在皮质形成过程中展示了感官模式整合的机制.
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