神经感官对环境线索的感知调节了精子运动,这对于受精至关重要
Katherine McKnight1, Hieu D Hoang2, Jeevan K Prasain3
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Science (New York, N.Y.)
|May 17, 2014
概括
环境线索通过改变精子功能来影响生育能力. 由女性神经系统感知到的费洛蒙会影响卵管状况,影响精子的运动性并引导它们到卵细胞.
科学领域:
- 生殖生物学 生殖生物学
- 神经内分泌学神经内分泌学
- 环境科学环境科学
背景情况:
- 环境暴露可能会损害性质细胞的功能和生育能力.
- 连接环境线索与生殖成功的确切机制尚未完全理解.
- 神经系统在调解这些环境对生育的影响中的作用是一个正在积极研究的领域.
研究的目的:
- 阐明环境暴露影响生育能力的机制.
- 研究费洛蒙和神经系统在调节精子功能的作用.
- 确定涉及环境感知和生殖结果的信号通路.
主要方法:
- 利用Caenorhabditis elegans作为一种模型生物来研究神经元对费洛蒙的感知.
- 研究了神经元信号传递对卵巢脂质微环境的影响.
- 在C. elegans和Cox淘汰赛小鼠中分析了前列腺素合成途径.
主要成果:
- 在C. elegans中状神经元检测费洛蒙会改变卵巢脂质微环境,影响精子运动.
- 费洛蒙敏感神经元分泌DAF-7,一种转化生长因子-β连接体,刺激卵巢中的前列腺素合成.
- 卵细胞合成指导精子的F类前列腺素,这一过程观察到独立于循环氧化酶 (Cox) 并可能在小鼠中保存.
结论:
- 由女性神经系统感知到的环境线索直接影响精子功能和运动性.
- 神经内分泌信号传递,涉及DAF-7和前列腺素,在调解环境对生育的影响方面发挥着至关重要的作用.
- 这些发现表明,物种之间存在环境感知和生育调节的保存机制.
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