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快速,水溶性稳定的化物终端蛋白质和菌体库的修饰

Pavel I Kitov1, Daniel F Vinals, Simon Ng

  • 1Department of Chemistry, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.

Journal of the American Chemical Society
|May 23, 2014
PubMed
概括

2-氨基胺胺 (ABAO) 衍生物与水中的化物快速反应,形成二基纳产物. 这种生物直角反应的效率很高,这表明开发新的光探针的潜力.

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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