动力转移稳定的Fe(II) 2L3三重螺旋的组装后修改
Derrick A Roberts1, Ana M Castilla, Tanya K Ronson
1Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Journal of the American Chemical Society
|May 27, 2014
概括
我们使用共价后组装修改稳定了非平衡铁(II) 三重螺旋体. 这种策略可以防止结构变化,并允许合成复杂的分子,如-酸组件.
科学领域:
- 协调化学 协调化学
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
背景情况:
- 动力变态稳定的金属有机复合体经常重组为热力学稳定的结构.
- 控制复杂的超分子架构的组装和稳定性是一个重大挑战.
- 已知含氨酸的铁(II) 螺旋体存在于转移稳定的形式.
研究的目的:
- 开发一种用于稳定动态转移稳定的铁的方法.
- 调查用于结构控制的共价后组装修改的使用.
- 为了访问复杂的更高阶金属超分子结构.
主要方法:
- 合成含氨酸的Fe (II) 2L3三重螺旋体.
- 使用乙化和亚化反应进行共价后组装修改.
- 修改和未修改的螺旋飞机的结构特征.
- 谱学和晶体学分析.
主要成果:
- 成功对转移稳定的Fe(II) 2L3三重螺旋体进行了共价性修饰.
- 防止螺旋到的结构重组.
- 不平衡螺旋结构的稳定.
- 促进了一种更高阶的tris ((porphyrinatoruthenium) -helicate复合物的合成.
结论:
- 性后组装修改是一种稳定转移稳定的超分子结构的有效策略.
- 这种方法为复杂的金属超分子组件提供了一条途径,其它方法不容易获得.
- 功能化方法为设计和构建先进的分子架构提供了新的可能性.
更多相关视频
相关概念视频
Disassembly of Intermediate Filaments
2.0K
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
2.0K
Cycloaddition Reactions: MO Requirements for Thermal Activation
29.7K
Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
29.7K
Complexation Equilibria: Factors Influencing Stability of Complexes
992
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
992


