通过H10型流感病毒的受体结合
Sebastien G Vachieri1, Xiaoli Xiong1, Patrick J Collins2
11] MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK [2].
Nature
|May 30, 2014
概括
禽流感H10N8病毒对人类受体具有高度亲和力,构成公共卫生威胁. 虽然它可以感染人类,但它对鸟类受体的偏好可能会限制广泛传播.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 结构生物学 结构生物学
背景情况:
- 禽流感病毒,如H5N1和H7N9,由于它们有可能感染人类,因此构成重大公共卫生风险.
- H10N8病毒最近出现,有记录的人类病例和死亡人数,需要了解其流行病潜力.
研究的目的:
- 调查H10N8禽流感病毒的流行潜力.
- 为了确定H10N8病毒血凝素的受体结合特性.
- 分析与人类受体复合的H10N8血质素的结构特征.
主要方法:
- 确定禽类H10病毒的血凝素结构.
- 对H10病毒的受体结合性质的分析.
- 对与人类受体复合的禽类H10血凝素的晶体学研究.
主要成果:
- H10N8病毒对人类受体表现出高度的嗜好.
- 结构分析显示,结合的人类受体构造与1918年H1N1大流行病毒和人类H7病毒共享特征.
- H10N8病毒对人类受体具有足够的嗜好,可以引起人类感染.
结论:
- 禽类H10N8病毒具有人类受体感染人类所需的敏捷性.
- 病毒对鸟类受体的偏好可能会被人类的呼吸道真菌所抵消,这可能会限制广泛的人与人之间的传播.
- 监测应重点关注H10血凝素的受体结合部位的突变,这些突变会降低鸟类受体的兴奋度,从而可能增加人类的传染性.
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