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在小鼠胚胎表皮质细胞中,RLIM对于X染色体失活是不可或缺的

JongDae Shin1, Mary C Wallingford2, Judith Gallant3

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA.

Nature
|May 30, 2014
PubMed
概括

在雌性小鼠中,随机X染色体失活 (rXCI) 时,无素酶RLIM并不必不可少. 缺乏RLIM的胚胎细胞仍然经历XCI,这表明RLIM独立的机制激活了Xist.

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