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Anionic Chain-Growth Polymerization: Overview

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

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Preparation and Friction Force Microscopy Measurements of Immiscible, Opposing Polymer Brushes

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兹维特里昂聚氨基酸甲烯酸 (Zwitterionic poly(氨基酸甲烯酸) 刷子

Abdullah M Alswieleh¹, Nan Cheng, Irene Canton

¹Department of Chemistry, University of Sheffield , Brook Hill, Sheffield S3 7HF, United Kingdom.

Journal of the American Chemical Society

|June 3, 2014

概括

一种基于氨酸的新型单体 (CysMA) 形成了响应pH的聚合物刷. 这些聚氨酸甲酸 (PCysMA) 刷子抗生物污染,表现出低细胞毒性,并且可以为生物分子结合做图案.

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科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
表面科学是一门学科.

背景情况:

开发用于生物医学应用的先进聚合物刷具有至关重要的意义.
基于氨酸的单体为表面修饰提供了独特的功能.
需要适应pH值,生物惰性和可采样的聚合物涂层.

研究的目的:

为了合成一种新的基于氨酸的甲烯基单体 (CysMA).
在晶片上制造聚氨酸甲酸盐 (PCysMA) 刷子.
为了研究PCysMA刷子的pH响应性行为,生物污染抵抗性,细胞毒性和图案设计能力.

主要方法:

通过提亚-迈克尔添加合成CysMA.
从晶片中移植PCysMA刷子,使用原子转移激素聚合 (ATRP).
使用原子力显微镜 (AFM),泽塔电位测量,X射线光电子谱学 (XPS) 和共聚焦显微镜进行表征.

主要成果:

PCysMA刷具备pH值依赖的延伸,在pH值2以下和pH值9.5以上高度延伸.
在生理pH下,PCysMA刷子表现出极好的抗生物污染性和微不足道的细胞毒性.
在紫外线下的光降解会产生表面基团,用于随后的氨基合,从而使微型图案和生物分子固定 (例如GFP) 成为可能.

结论:

CysMA是一种多用途的单体,用于创建功能性聚合物刷.
PCysMA 刷子具有可调节的特性,良好的生物相容性,并可用于先进的表面工程.
可光降解性和反应性基组为创建复杂生物材料和设备打开了道路.