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Updated: Apr 28, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
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PDZ域结合动机调节心肌细胞区特定的NaV1.5通道表达和功能

Diana Shy1, Ludovic Gillet1, Jakob Ogrodnik1

  • 1From the Department of Clinical Research, University of Bern, Bern, Switzerland (D.S., L.G., J.O., M.A., J.-S.R., M.C.E., N.S., H.A.); Department of Anatomy, Embryology and Physiology (A.O.V.) and Department of Clinical and Experimental Cardiology (R.W., J.B., R.F.M., C.R.B., C.A.R.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.B.); Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands (A.M.v.M.); Institute of Pathology, University of Lausanne, Lausanne, Switzerland (S.R.); Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche 1087, L'Institut du Thorax, Nantes, France (R.R.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 6291, Nantes, France (R.R.); Université de Nantes, Nantes, France (R.R.); and Centre Hospitalier Universitaire Nantes, L'Institut du Thorax, Service de Cardiologie, Nantes, France (R.R.).

Circulation
|June 5, 2014
PubMed
概括

心脏道NaV1.5的Ser-Ile-Val (SIV) 动图对于其在侧面肌细胞膜的表达至关重要,影响心脏导电. 这种基因的突变与布鲁加达综合征有关,突出其临床相关性.

关键词:
消极蛋白质是一种消极蛋白质.的道是一种的道.合成氨基的作用是什么

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