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Updated: Apr 28, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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BRCA2 阻止了 R 循环积累,并与 TREX-2 mRNA 出口因子 PCID2 相关联

Vaibhav Bhatia1, Sonia I Barroso1, María L García-Rubio1

  • 1Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain.

Nature
|June 5, 2014
PubMed
概括

与衰老和癌症相关的基因组不稳定性,可以来自称为R-循环的RNA-DNA混合体. TREX-2复合物防止这种不稳定性,而BRCA2处理R环,突出了它们在癌症相关基因组不稳定性中的作用.

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