Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Long-term Potentiation01:35

Long-term Potentiation

51.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.5K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Long-term Depression01:05

Long-term Depression

27.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.2K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.8K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.8K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Lateral Habenula to Ventral Tegmental Area Pathway is Required for Aversive Learning and Defensive Behaviors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Review: "The Disappointment Dilemma: Short- and Long-Term Learning From Negative Outcomes".

The European journal of neuroscience·2026
Same author

How ketamine works: An actionable hypothesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Transcriptional Profiling of the Cortico-Accumbal Pathway Reveals Sex-Specific Alterations Underlying Stress Susceptibility.

Biological psychiatry·2025
Same author

Dual-color optical activation and suppression of neurons with high temporal precision.

eLife·2025
Same author

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit?

Cells·2024
Same journal

Daily briefing: How cooperation built the world.

Nature·2026
Same journal

Deep-sea oddities and boatloads of other new species - June's best science images.

Nature·2026
Same journal

From cloning to gene-editing: the enduring legacy of Dolly the sheep.

Nature·2026
Same journal

Time to give hydration breaks the red card? What science says about keeping cool.

Nature·2026
Same journal

Universities are relying on AI-detection software to catch cheating. How well do the programs work?

Nature·2026
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
查看所有相关文章

相关实验视频

Updated: Apr 28, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
11:13

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

13.7K

使用 LTD 和 LTP 设计一个内存.

Sadegh Nabavi1, Rocky Fox1, Christophe D Proulx2

  • 11] Center for Neural Circuits and Behavior, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, California 92093, USA [2].

Nature
|June 5, 2014
PubMed
概括
此摘要是机器生成的。

科学家们证明,长期抑郁 (LTD) 可以使恐惧记忆失活,而长期强化 (LTP) 可以使它们重新激活. 这项研究提供了因果证据,将突触可塑性与记忆联系起来.

更多相关视频

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.7K
Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.6K

相关实验视频

Last Updated: Apr 28, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
11:13

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

13.7K
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.7K
Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.6K

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 记忆研究 记忆研究

背景情况:

  • 假设记忆编码涉及突触可塑性,特别是长期强化 (LTP) 和长期抑郁 (LTD).
  • 建立这些突触机制和记忆之间的直接因果关系在神经科学中仍然是一个重大挑战.

研究的目的:

  • 调查LTP和LTD在关联性恐惧记忆的失活和重新激活中的因果作用.
  • 通过有针对性的突触修改来证明记忆回忆的直接操纵.

主要方法:

  • 在动物模型中利用光遗传学来刺激针对杏仁体的听觉输入.
  • 应用了LTD调节来禁用与脚震动相关的恐惧记忆.
  • 应用LTP调节来重新激活失活的恐惧记忆.

主要成果:

  • 通过光遗传诱导的LTD成功地使条件恐惧记忆失活.
  • 随后的光遗传诱导的LTP重新激活了以前失活的恐惧记忆.
  • 通过突触可塑性操纵,通过突触可塑性操纵,证明了对记忆状态 (非激活/重新激活) 的精确控制.

结论:

  • 提供了强有力的因果证据,将长期抑郁症 (LTD) 和长期强化 (LTP) 与记忆失活和重新激活的机制联系起来.
  • 支持突触可塑性是记忆形成和回忆的基本细胞基础的假设.
  • 突出了有针对性的突触调制在理解和潜在的治疗与记忆有关的障碍的潜力.