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Updated: Apr 28, 2026

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心脏纤维细胞糖原合成酶激酶-3β调节心室重塑和缺血性心脏功能障碍

Hind Lal1, Firdos Ahmad1, Jibin Zhou1

  • 1From the Center for Translational Medicine (H.L., F.A., J.Z., J.E.U., R.J.V., Y.G., E.G., T.F.), Department of Clinical Sciences (D.Y.), and Section of Cardiology (E.J.T., T.F.), Temple University School of Medicine, Philadelphia, PA; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada (J.W.); and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (H.L., F.A., Y.G., T.F.).

Circulation
|June 6, 2014
PubMed
概括

抑制糖原合成酶激酶-3β (GSK-3β) 通过激活肌纤维细胞和TGF-β1/SMAD-3信号传递,促进心脏纤维化. 向GSK-3β可能治疗心肌纤维性疾病.

关键词:
纤维细胞的细胞.有纤维化的纤维化.糖原合成酶激酶3ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ过度缩的过度缩是一个问题.心肌梗塞的心脏病发作

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