石类是一种调节免疫脂肪相互作用的激素,以增加色脂肪热生成
Rajesh R Rao1, Jonathan Z Long1, James P White1
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|June 7, 2014
概括
流星类 (Metrnl) 是一种新发现的运动诱导因素,可以增加能量消耗并改善葡萄糖耐受性. 运动和暴露在寒冷中与代谢调节和炎症控制有关,具有治疗潜力.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 免疫学 免疫学 免疫学
背景情况:
- 运动训练可以防止肥胖和糖尿病等代谢障碍.
- PGC1-α4异型被用作用于新型因子发现的工具.
研究的目的:
- 为了识别运动和寒冷暴露引起的新型循环因素.
- 研究石类物质 (Metrnl) 在调节能量稳态和炎症中的作用.
主要方法:
- 在运动后的肌肉和冷暴露后的脂肪组织中识别Metrnl.
- 在体内研究以评估Metrnl对能量消耗,葡萄糖耐受性和基因表达的影响.
- 研究Metrnl的机制,涉及乙素,IL-4和脂肪组织巨细胞.
主要成果:
- 在肌肉和脂肪组织中引入美特林.
- 增加的Metrnl水平增加能量消耗,改善葡萄糖耐受性,并促进发热性和抗炎性基因表达.
- 梅特林调解了依赖于乙氨基酸的IL-4产生和替代性巨细胞激活,这对于脂肪的发热和抗炎反应至关重要.
- 阻断Metrnl抑制冷诱导的巨细胞激活和发热的基因表达.
结论:
- 铁作为循环因子,将运动和寒冷适应与能量平衡和炎症联系起来.
- 梅特林在激活脂肪组织中发热和抗炎途径方面发挥着关键作用.
- 甲在代谢和炎症性疾病中具有治疗潜力.
相关概念视频
Inflammation
Overview
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Lipids: Dietary Sources and Requirements
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Cholesterol: Significance and Regulation
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
Sulfur Assimilation
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...
Cholecystitis
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...


![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)