相关实验视频
Updated: Apr 28, 2026

08:56
Derivation of Glial Restricted Precursors from E13 mice
Published on: June 20, 2012
12.8K
神经发育. 神经发育. 副交感神经元起源于与神经相关的外周质细胞原始体
Vyacheslav Dyachuk1, Alessandro Furlan2, Maryam Khatibi Shahidi3
1Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia.
概括
小鼠的副交感神经元来源于与神经相关的质细胞,而不是神经细胞. 这一发现揭示了这些重要神经细胞的新起源,影响了我们对神经系统发育的理解.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 周围自主神经系统 (PANS) 包含对同情和副同情神经元,这些神经元对于调节身体功能至关重要.
- 副交感神经元的发育起源传统上归因于神经细胞.
研究的目的:
- 研究小鼠外交神经元在外周神经系统中的细胞起源.
- 挑战对寄同情神经元发育的既定理解.
主要方法:
- 在小鼠中使用多色Cre-reporter血统追踪.
- 检查了干干细胞和头骨干细胞,包括状,状,舌状,下状和耳腔干细胞.
主要成果:
- 证明了副交感神经元来自神经中的质细胞,特别是施万细胞前体.
- 确定了产生质细胞和神经元的双强原始体.
- 显示了寄同情命运在远端外围部位被诱导.
结论:
- 副交感神经元起源于与神经相关的质前体,而不是神经细胞.
- 这种神经衍生源提供了细胞元素,用于在各种组织中产生副交感神经元.
- 建议一种机制,可以有效地连接发育中的副交感神经系统.
相关概念视频
Glial Cells
75.1K
Overview
75.1K
Nervous Tissue: Glial Cells
12.0K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
12.0K
Peripheral Nervous System: Ganglia and Nerves
7.8K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
7.8K
Neurogenesis and Regeneration of Nervous Tissue
2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K
Neurulation
40.1K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.1K
Cranial Part of Parasympathetic Division
2.6K
The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
2.6K

