饮酒模式和心肌梗塞风险:INTERHEART病例控制研究中52个国家的观察结果
Darryl P Leong1, Andrew Smyth2, Koon K Teo2
1From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (D.P.L., A.S., K.K.T., S.R., S.S.A., S.Y.); London School of Hygiene and Tropical Medicine, London, UK (M.M.); St. John's Medical College, Bangalore, India (P.P.); and Fu Wai Hospital, Beijing, China (L.L.). leongd@phri.ca.
Circulation
|June 15, 2014
概括
适度饮酒可能会降低心肌梗塞 (MI) 风险,但大量的偶尔饮酒会增加风险,特别是在老年人中. 饮酒模式的区域差异可能会影响这些结果.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 适度饮酒与心肌梗塞 (MI) 风险降低有关.
- 酒精心脏保护作用的全球概括性和区域差异尚不清楚.
- 沉重的插曲性饮酒对MI风险在不同人群中的影响需要调查.
研究的目的:
- 评估酒精消费模式与心肌梗塞 (MI) 风险之间的全球联系.
- 调查饮酒模式的区域差异是否会改变酒精对MI的影响.
- 检查与重度偶尔饮酒相关的特定风险.
主要方法:
- 一项病例控制研究,涉及来自52个国家的12,195例初发性心脏病例和15,583例对照.
- 分析将目前的酒精使用者与非使用者进行了比较,考虑到区域差异.
- 评估重度插曲性饮酒 (24小时内≥6杯饮料) 和其与心脏病发作风险的关联.
主要成果:
- 目前的酒精使用表明心脏病发作风险降低 (OR,0.87;P=0.001),但这在不同地区有显著差异 (P<0.001).
- 在24小时内频繁饮酒与心脏病发作风险增加有关 (OR,1.4;P=0.01).
- 在65岁以上的人群中,因大量饮酒而导致心脏病发作的风险明显更高 (OR,5.3;P=0.008).
结论:
- 对大多数参与者来说,低饮酒与中风风险的适度降低有关.
- 酒精的心脏保护作用在全球范围内不均,可能会受到区域饮酒习惯的影响.
- 急性重度饮酒会增加24小时内心脏病发作风险,特别是在老年人中.
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