海马的独特的依赖于血统的结构和功能组织
Hua-Tai Xu1, Zhi Han2, Peng Gao3
1Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Cell
|June 21, 2014
概括
发展中的海马刺激神经元形成水平集群,而不是垂直集群. 姐妹神经元很少发生突触,但共享抑制输入,表明记忆和导航中的功能单元.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 海马对于记忆和空间导航至关重要.
- 海马体的细胞组织尚未完全理解.
- 以前的研究集中在神经生理学上,不清楚发育过程.
研究的目的:
- 为了研究海马体发育激发神经元的细胞组织.
- 了解海马体中的姐妹刺激神经元如何形成连接和功能单元.
主要方法:
- 细胞类型特定的逆转录病毒标签.
- 用双标记器进行马赛克分析 (MADM).
- 对海马神经元中突触连接和活动的分析.
主要成果:
- 在海马体中,与细胞系相关的刺激神经元形成横向的,而不是垂直的集群.
- 在cornu ammonis 1区域的姐妹刺激神经元很少形成直接的突触连接.
- 姐妹神经元优先从快速激增 (FS) 内神经元接收共同的输入,从而导致同步活动.
结论:
- 来自FS内部神经元的共享抑制输入可以将水平聚集的姐妹刺激神经元定义为功能单元.
- 这种组织与新皮层发育有所不同.
- 提供了对海马体电路形成和功能的洞察.
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