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Updated: Apr 27, 2026

CRISPR-Cas9-based Genome Engineering to Generate Jurkat Reporter Models for HIV-1 Infection with Selected Proviral Integration Sites
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艾滋病毒潜伏期. 特定的HIV整合部位与感染细胞的克隆扩张和持久性有关

F Maldarelli1, X Wu2, L Su2

  • 1HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.

Science (New York, N.Y.)
|June 28, 2014
PubMed
概括

人类免疫缺陷病毒 (HIV) 的DNA集成到宿主基因组中,即使在治疗中也在受感染的细胞中持续存在. 这些融合点驱动HIV感染细胞的扩张和长期存活,阻碍了治愈.

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