静脉血栓塞栓症后的30年死亡率:基于人口的队列研究
Kirstine Kobberøe Søgaard1, Morten Schmidt2, Lars Pedersen2
1From the Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. kks@clin.au.dk.
Circulation
|June 28, 2014
概括
静脉血栓塞栓症 (VTE) 患者面临更高的长期死亡风险,特别是在诊断后的第一年内. 这种风险持续30年,VTE是死亡的重要原因,尽管肺栓塞的30天死亡率有所改善.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 静脉血栓塞栓症 (VTE) 后的长期死亡数据有限.
- 静脉瘤,包括深静脉血栓症 (DVT) 和肺栓塞 (PE),对健康造成重大负担.
研究的目的:
- 在30年的时间内调查与首次VTE相关的长期死亡风险.
- 为了比较VTE患者的死亡率与匹配的一般人口队列.
主要方法:
- 在丹麦 (1980-2011) 进行了一项全国性的基于人口的队列研究.
- 包括128,223名首次出现VTE的患者和640,760名匹配的对照.
- 利用丹麦医学数据库和考克斯回归分析来确定死亡率比率 (MRR).
主要成果:
- 静脉瘤患者的死亡风险明显高于对照组,特别是在诊断后的30天和第一年内.
- 总体而言,30年MRR为DVT的1.55和PE的2.77.
- 虽然30天DVT死亡率保持稳定,但PE死亡率在30年内显著改善.
结论:
- 在30年的随访期间,静脉瘤患者面临高死亡风险.
- 静脉瘤是导致死亡的重要因素,特别是在诊断后的第一年.
- 对于PE的30天死亡率的改善表明护理的进步,而DVT死亡率仍然令人担忧.
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